Our research.Our research interest is neuroscience with focus on neuropathological diseases (Alzheimer’s disease, Parkinson’s disease, Pick disease, Down syndrome, etc.), synaptic plasticity, and brain network communication (Hippocampus, medial septum-diagonal band of Broca and The retrosplenial cortex ). Our working hypothesis is that modified tau has tremendous implications in synaptic response and therefore in network activity, therefore our objective is to find the mechanistic relationship between modified tau protein and synaptic activity and ultimately its relationship to network function. The final objective is to elucidate new therapeutic targets and strategies to prevent neurodegenerative diseases.
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NeuropathologyWe study disease of nervous system tissue, in the form of either small surgical biopsies or whole-body autopsies.
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Brain recordingsWe do electrophysiological recordings of spiking and local field potentials in vitro and in virtual reality environment.
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Molecular BiologyWe use molecular biology techniques that are at the forefront of most cutting edge scientific research.
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Mondragón Rodríguez SiddharthaSiddhartha Mondragon-Rodriguez graduated in Chemical Engineering from Michoacan University of Saint Nicolas of Hidalgo (UMSNH) in 1996 - 2002. Master Degree (MsC) in Molecular Biomedicine from National School of Medicine from the National Polytechnic Institute of Mexico City in 2003 - 2005. PhD from Center of Research and Advanced Studies of the National Politechnical Institute in 2005 – 2009. Research Invited at Case Western Reserve University, Department of Pathology, Cleveland Ohio, US, in 2006 - 2007. Posdoctoral Fellow from Universite de Montreal in 2009 - 2012. Faculte de Medecine, Departament de Physiologie., Montreal, Qc, Canada. Posdoctoral Fellow from McGill University. Faculte de Medicine, Department of Psychiatry, Montreal, Qc, Canada from 2012 to 2014. Currently at the Institute of Neurobiology, UNAM, Querétaro, México as Associate Professor for The National Council for Science and Technology (CONACyT), México, Mex.
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Specific research DirectionsOur final objective is to elucidate new therapeutic targets and strategies to prevent neurodegenerative diseases.
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