About.Our results provide new insights into Alzheimer’s pathogenesis and suggest that increases in Tau phosphorylation at the initial stages of the disease represent neuronal responses that compensate for brain circuit overexcitation.
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Selected publicationsXolalpa-Cueva L, García-Carlos CA, Villaseñor-Zepeda R, Orta-Salazar E, Díaz-Cintra S, Peña-Ortega F, Perry G, Mondragón-Rodríguez S. Hyperphosphorylated Tau Relates to Improved Cognitive Performance and Reduced Hippocampal Excitability in the Young rTg4510 Mouse Model of Tauopathy.J Alzheimers Dis. 2022;87(2):529-543. doi: 10.3233/JAD-215186.
Mondragón-Rodríguez, Siddhartha, Ning Gu, Frederic Manseau, and Sylvain Williams. 2018. “Alzheimer’s Transgenic Model Is Characterized by Very Early Brain Network Alterations and β-CTF Fragment Accumulation: Reversal by β-Secretase Inhibition.” Frontiers in Cellular Neuroscience 12 (May): 121. doi:10.3389/fncel.2018.00121. Mondragón Rodríguez, Siddhartha, Anahí Salas Gallardo, Perla Gonzalez Pereyra, Martín Macías, Benito Ordaz, Fernando Peña Ortega, Azucena Aguilar Vazquez, et al. 2018. “Phosphorylation of Tau Protein Correlates with Changes in Hippocampal Theta Oscillations and Reduces Hippocampal Excitability in Alzheimer’s Model.” Journal of Biological Chemistry, April, jbc.RA117.001187. doi:10.1074/jbc.RA117.001187. Mondragón-Rodríguez, S., G. Perry, F. Peña-Ortega, and S. Williams. 2017. “Tau, Amyloid Beta and Deep Brain Stimulation: Aiming to Restore Cognitive Deficit in Alzheimer’s Disease.” Current Alzheimer Research 14 (1). doi:10.2174/1567205013666160819131336. Mondragón-Rodríguez, S., G. Perry, and F. Peña-Ortega. 2016. Tau Proteins. Drug Discovery Approaches for the Treatment of Neurodegenerative Disorders: Alzheimer’s Disease. doi:10.1016/B978-0-12-802810-0.00008-8. Mondragón-Rodríguez, S., G. Perry, J. Luna-Muñoz, M. C. Acevedo-Aquino, and S. Williams. 2014. “Phosphorylation of Tau Protein at Sites Ser396-404 Is One of the Earliest Events in Alzheimer’s Disease and Down Syndrome.” Neuropathology and Applied Neurobiology 40 (2): 121–35. doi:10.1111/nan.12084. Mondragón-Rodríguez S, Perry G, Zhu X, Moreira PI, Acevedo-Aquino MC, Williams S. 2013. “Phosphorylation of Tau Protein as the Link between Oxidative Stress, Mitochondrial Dysfunction, and Connectivity Failure: Implications for Alzheimer’s Disease.” Oxidative Medicine and Cellular Longevity 2013: 1–6. doi:10.1155/2013/940603. Mondragon-Rodriguez, Siddhartha, Emilie Trillaud-Doppia, Anthony Dudilot, Catherine Bourgeois, Michel Lauzon, Nicole Leclerc, and Jannic Boehm. 2012. “Interaction of Endogenous Tau with Synaptic Proteins Is Regulated by NMDA-Receptor Dependent Tau Phosphorylation.” The Journal of Biological Chemistry 287 (38): 32040–53. doi:10.1074/jbc.M112.401240. |
Our Team
Lorena Xolalpa Cueva
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José Ma Cornejo Montes
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Sheini Ruturi Sánchez G
PhD student UAQ, Queretaro, Mex. |